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A Simple, Fast, and Versatile Method for Selective Bromination of Indole Alkaloids


The development of drugs through chemical modifications of naturally occurring indole alkaloids has emerged as an attractive research area. However, due to their reactivity, the selective functionalization at the C5 position of the indole ring has been difficult. Recently, researchers developed a new one-step method for C5-selective bromination of indole alkaloids. It is simple, fast, mild, and can accommodate various functional groups. This innovative method can lead to the development of new drugs and agrochemicals.


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