News & Events

How "Extracellular Chaperones" Help Remove Abnormal Proteins


When exposed to stressful conditions, several proteins tend to misfold and form aggre-gates inside or outside cells. These aggregates, if accumulated, may contribute to age-related disorders, including Alzheimer's disease. Extracellular chaperones stabilize mis-folded proteins to prevent their aggregation and have been implicated in clearing these defective proteins outside cells, but their mechanisms are poorly understood. Now, re-searchers from Chiba University have developed an assay that can detect this process quantitatively and have uncovered that extracellular chaperones mediate the lysoso-mal degradation of extracellular misfolded proteins.

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