New Study Expands the Scope of Aza-Friedel−Crafts Reactions
2023.07.20
Selective addition of substituents to specific positions in organic compounds has been instrumental in producing a wide range of products. In a groundbreaking study, scientists from Chiba University, Japan, introduced a novel catalyst called bulky PyBidine-Ni(OAc)2 for the aza-Friedel−Crafts reaction of phenols with imines. The catalyst preferably generates para-substituted products instead of conventional ortho-substituted products, considerably expanding the possibilities for synthesizing novel compounds.
