New Study Links Intestinal Glycan Modifications to Obesity and Inflammation
2023.10.11
Mucins are glycoproteins present in the gastrointestinal lining that protect the body against external invasions. Although mucin dysfunction is known to trigger disease and inflammation, the underlying mechanisms have remained elusive thus far. A recent study led by a Japanese research team describes how the N-acetylglucosamine (GlcNAc)-6-O-sulfation of O-glycans, the modification of the glycan structures found in mucins, helps combat obesity and intestinal inflammation in a murine model.
