NMR-Guided Optimization of Lipid Nanoparticles for Enhanced siRNA Delivery
2024.10.01
siRNA therapies show promise for treating diseases like cancer and genetic disorders, but their effectiveness depends on proper delivery. A recent study found that the method of mixing siRNA with lipid nanoparticles (LNPs) is key to success. Using NMR and small-angle X-ray scattering (SAXS), researchers revealed that different preparation methods affect the internal structure and siRNA distribution in LNPs, impacting their therapeutic potential. Optimizing these methods can enhance the efficacy of siRNA-loaded LNPs.
