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Towards A Better Understanding of Early Human Embryonic Development


Despite being an essential developmental process, the understanding of human embryonic genome activation is limited, owing to the lack of in vitro cell models and ethical concerns. To advance understanding, five independent research groups have recently developed human 8-cell-like cells (8CLCs) from pluripotent stem cells using different approaches. In a new study, researchers now compare the transcriptomic profiles of these 8CLCs and human pre-implantation embryos to facilitate the use of 8CLCs as cell models.


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